HCID 66777839, compound → HCID 66779319, compound

Participants

Reaction Steps

Ethyl 3-[{[6-({1-[5-(cyclopropylmethoxy)-3-methyl-1-benzofuran-2-yl]-2-methylpropyl}amino)pyridin-3-yl]carbonyl}(methyl)amino]propanoate (100 mg) synthesized in Example A210 was dissolved in ethanol (0.5 mL)-tetrahydrofuran (0.5 mL), 1N aqueous sodium hydroxide solution (0.4 mL) was added to the solution, and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure, water (0.5 mL) was added to the residue, and the mixture was neutralized with 1N hydrochloric acid (0.4 mL) under ice-cooling, and the mixture was stirred for 20 min. The resulting precipitate was collected by filtration, and dried to give the title compound (77 mg, 80%) as a colorless solid.

Provenance & Evidence