Tetrahydrofuran → HCID 66777998, compound

Participants

Reaction Steps

To a mixture of methyl 5-({1-[5-(cyclopropylmethoxy)-3-methyl-1-benzofuran-2-yl]-2-methylpropyl}amino)pyridine-2-carboxylate (410 mg) synthesized above, tetrahydrofuran (2.0 mL) and ethanol (2.0 mL) was added 1N aqueous sodium hydroxide solution (2.0 mL), and the mixture was stirred with heating under reflux for 14 hr. The reaction mixture was concentrated under reduced pressure, water (4 mL) was added to the residue, 1N hydrochloric acid (2 mL) was added under ice-cooling, and the mixture was stirred for 20 min. The resulting precipitate was collected by filtration, and dried to give the title compound (323 mg, 80%) as a colorless solid.

Provenance & Evidence