Sodium Hydroxide → HCID 66777778, compound

HRID 2091428Notes

Reaction equation

HRID 2091428 reaction equation
[CH:1]1([CH:7]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([N:29]([CH3:37])[CH2:30][CH2:31][C:32]([O:34]CC)=[O:33])=[O:28])=[CH:23][CH:22]=2)[C:8]2[O:9][C:10]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:11]=3[C:12]=2[O:13][CH3:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([CH:7]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([C:27]([N:29]([CH3:37])[CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])=[CH:25][CH:26]=2)[C:8]2[O:9][C:10]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:11]=3[C:12]=2[O:13][CH3:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66777971HCID 66777971, compound2×

Product 1

HCID 66777778HCID 66777778, compoundYield 52.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 3-{[(4-{[cyclohexyl(5-fluoro-3-methoxy-1-benzofuran-2-yl)methyl]amino}phenyl)carbonyl](methyl)amino}propanoate (0.30 g) synthesized in the above-mentioned (4) was dissolved in ethanol (5 mL), 1N aqueous sodium hydroxide solution (1.0 mL) was added to the solution at room temperature, and the mixture was stirred at room temperature for 0.5 hr. Ethanol was evaporated under reduced pressure, and 1N hydrochloric acid (1.0 mL) was added to the residue. The precipitate was washed with water to give the title object compound (0.15 g, 52%) as a colorless solid.

Workup

  1. customEthanol was evaporated under reduced pressure, and 1N hydrochloric acid (1.0 mL)
  2. additionwas added to the residue
  3. washThe precipitate was washed with water

Sources & evidence

ORD record
ord-822b34e4a0e84be09421c93f80b290af
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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