Hydrochloric Acid → HCID 66778469, compound

Participants

Reaction Steps

To a mixture of cyclohexyl(6-methoxy-2-methyl-1-benzofuran-3-yl)methanone (1.18 g) synthesized above, methanol (1 mL) and tetrahydrofuran (10 mL) was added sodium borohydride (246 mg) at 0° C., and the mixture was stirred for 30 min. 1N Hydrochloric acid was added to quench the reaction, the organic solvent was evaporated in an evaporator, and the residue was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give the title object compound (906 mg, 76%) as a pale-yellow oil.

Provenance & Evidence