Sodium Hydroxide → HCID 57939192, compound

HRID 2091474Notes

Reaction equation

HRID 2091474 reaction equation
[OH-].[Na+].[CH2:3]([O:14][C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=1)[C:18]([O:20]C)=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>CO>[CH2:3]([O:14][C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=1)[C:18]([OH:20])=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57939218HCID 57939218, compound

Product 1

HCID 57939192HCID 57939192, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

600 L of 1 N sodium hydroxide solution (600 μmol) are added portionwise to 112 mg of 21 (366 μmol) in methanol (4 mL). The solution is refluxed for two hours. After evaporating off the solvent, the reaction medium is acidified with 0.5 N HCl and extracted with DCM. 107 mg of the expected acid are obtained in the form of a white solid, i.e. a yield of 99%.

Workup

  1. temperatureThe solution is refluxed for two hours
  2. customAfter evaporating off the solvent
  3. extractionextracted with DCM

Sources & evidence

ORD record
ord-2fb194090ed24ba68a340bf283d6faae
Source dataset
uspto-grants-2013_05
Patent number
US08440591B2

Reaction notes

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