Sodium Hydroxide → HCID 57939223, compound

HRID 2091478Notes

Reaction equation

HRID 2091478 reaction equation
[OH-].[Na+].[CH2:3]([O:14][C:15]1[CH:24]=[CH:23][CH:22]=[CH:21][C:16]=1[C:17]([O:19]C)=[O:18])[CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>CO>[CH2:3]([O:14][C:15]1[CH:24]=[CH:23][CH:22]=[CH:21][C:16]=1[C:17]([OH:19])=[O:18])[CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57939225HCID 57939225, compound

Product 1

HCID 57939223HCID 57939223, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

500 μl of 1 N sodium hydroxide solution (500 μmol) are added portionwise to 80 mg of 29 (263 μmol) in methanol (3 mL). The solution is refluxed for 24 hours. After evaporating off the solvent, the reaction medium is acidified with 0.5 N HCl and extracted with DCM. 76 mg of a yellow oil are obtained, i.e. a yield of 99%.

Workup

  1. temperatureThe solution is refluxed for 24 hours
  2. customAfter evaporating off the solvent
  3. extractionextracted with DCM

Sources & evidence

ORD record
ord-4818f8831f5c45adb0fbb1c270128119
Source dataset
uspto-grants-2013_05
Patent number
US08440591B2

Reaction notes

Loading…