1,4-Dioxane hydrochloride → HCID 66989598, compound

HRID 2091549Notes

Reaction equation

HRID 2091549 reaction equation
C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:20]([CH2:32][O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:30])([CH3:29])[CH:23]=[C:22]3[CH3:31])=[C:15]([O:42][CH3:43])[CH:14]=1)=[O:11])=O)(C)(C)C.[ClH:44].O1CCOCC1>O1CCOCC1>[ClH:44].[NH2:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:20]([CH2:32][O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:30])([CH3:29])[CH:23]=[C:22]3[CH3:31])=[C:15]([O:42][CH3:43])[CH:14]=1)=[O:11]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 24798769HCID 24798769, compound

Product 1

HCID 66989598HCID 66989598, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

6-(4-t-Butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline (Reference Compound No. 4-1, 20.1 mg, 0.034 mmol) was dissolved in 1,4-dioxane (0.5 mL), 4N hydrogen chloride/1,4-dioxane solution (34 μL) was added thereto, and then the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure to give the titled compound (17.5 mg) as a colorless solid. (Yield 98%)

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-56a0f8b577244de692e6a3137511bb93
Source dataset
uspto-grants-2013_05
Patent number
US08440660B2

Reaction notes

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