HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2091559Generated: November 1, 2026
Tetramethyltin → N-ethyl-N-methyl-6-(trimethylstannyl)pyridine-3-sulfonamide
https://huagongshe.com/reaction/2091559
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetramethyltin | HCID 11661 | — |
| Reactant | 6-chloro-N-ethyl-N-methylpyridine-3-sulfonamide | HCID 43263448 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-ethyl-N-methyl-6-(trimethylstannyl)pyridine-3-sulfonamide | HCID 70655349 | 40.2% |
Reaction Steps
6-chloro-N-ethyl-N-methylpyridine-3-sulfonamide (2.34 g, 10.0 mmol), tetramethyl tin (1.08 g, 10.00 mmol) and Pd(PPh3)4 (572 mg, 0.50 mmol) were mixed in dioxane (5 mL). After degassing, the mixture was heated to 90° C. At completion, the reaction was cooled to room temperature and concentrated. The residue was then flashed over alumina (20-100% chloroform/hexane eluent) to afford N-ethyl-N-methyl-6-(trimethylstannyl)pyridine-3-sulfonamide (1.46 g, 40% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08440652B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-adf4e7f36cb848e8b7d52849d1df7af4 |
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| Source note | uspto-grants-2013_05 |
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