N-bromobutanimide → HCID 86670211, compound

Participants

Reaction Steps

To a solution of 4-(4-(5-aminopyrazin-2-yl)phenyl)tetrahydro-2H-pyran-4-carbonitrile (1.08 m, 3.84 mmol) in DMF (30 mL) was added N-bromosuccinimide (747 mg, 4.22 mmol) in one portion. The reaction was then stirred at room temperature for 1 h. At completion, the mixture was poured over ice (50 mL) and stirred for 20 min. After filtration and washing with water and drying under vacuum, 4-(4-(5-amino-6-bromopyrazin-2-yl)phenyl)tetrahydro-2H-pyran-4-carbonitrile was obtained as obtained as a dark brown solid (1.37 g, 100% yield).

Provenance & Evidence