Hydroxyamine hydrochloride → HCID 88876337, compound

Participants

Reaction Steps

A solution of 6′-bromospiro[cyclopropane-1,1′-inden]-3′(2′H)-one (2.1 g, 8.86 mmol), hydroxylamine HCl (1.23 g, 17.7 mmol) and NaOAc (4.32 g, 53.1 mmol) in MeOH (160 mL) was stirred overnight at room temperature. The reaction was concentrated, slurried water (40 mL), then sonicated and filtered. The precipitate was dried under high vacuum to give (E)-6′-bromospiro[cyclopropane-1,1′-inden]-3′(2′H)-one oxime (2.23 g, 100% yield) as a white solid. MS (EI) m/z=253.1[M+1]+.

Provenance & Evidence