Hydrochloric Acid → HCID 86670220, compound

Participants

Reaction Steps

To a solution of tert-butyl 6-chloro-1-oxo-3,4-dihydro-2,7-naphthyridine-2(1H)-carboxylate (3.0 g, 10.6 mmol) in DCM (20 mL) was added 4N HCl solution in dioxane (10 mL). After stirring 20 minutes at room temperature, the reaction was diluted with DCM (50 mL, then sonicated and filtered to give 6-chloro-3,4-dihydro-2,7-naphthyridin-1(2H)-one hydrochloride (2.22 g, 93% yield) as a white solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 8.70 (s, 1H), 8.23 (br. s., 1H), 7.57 (s, J=0.6 Hz, 1H), 3.40 (t, J=6.6, 2.8 Hz, 2H), 2.96 (t, J=6.6 Hz, 2H); MS (EI) m/z=183.6 [M+1]+.

Provenance & Evidence