HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl(4S)-5-azido-4-[(tert-butoxy)carbonylamino]pentanoate → (S)-tert-butyl 6-oxopiperidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl(4S)-5-azido-4-[(tert-butoxy)carbonylamino]pentanoate | HCID 10778574 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-tert-butyl 6-oxopiperidin-3-ylcarbamate | HCID 15466433 | 99.3% |
Reaction Steps
Methyl (4S)-5-azido-4-[(tert-butoxy)carbonylamino]pentanoate (3.9 mmol, 1.07 g) was dissolved in methanol (10 mL), and 10% palladium on carbon (0.1 g) was added. The reaction was stirred overnight under 1 atm of hydrogen. The reaction was filtered and the solvent was removed in vacuo to yield the title compound (0.83 g, 99% yield). ES-MS: 215 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440661B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-db7f73defe064266bbdd4ae4c751ea45 |
| Source note | uspto-grants-2013_05 |