HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ether hydrochloride → Evogliptin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ether hydrochloride | HCID 10953452 | — |
| Reactant | HCID 86641589 | HCID 86641589 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Evogliptin | HCID 25022354 | — |
Reaction Steps
97 mg of t-butyl (R)-4-[(R)-2-(t-butoxymethyl)-3-oxopiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate prepared in Step 8 was dissolved in 3 mL of methanol, followed by addition of 2 mL of 2N-hydrochloric acid/diethyl ether and stirring at room temperature for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440669B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-64be692956664655b9d5a747e3b1072f |
| Source note | uspto-grants-2013_05 |