1-(Thiomorpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid → {3-[3-(2-Ethoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone

HRID 2091748Notes

Reaction equation

HRID 2091748 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25]([OH:27])=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH2:28]([O:30][CH2:31][CH2:32][C:33](=[NH:36])[NH:34]O)[CH3:29]>>[CH2:28]([O:30][CH2:31][CH2:32][C:33]1[N:36]=[C:25]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=3)[CH2:14][N:9]([C:7]([N:1]3[CH2:6][CH2:5][S:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[O:27][N:34]=1)[CH3:29]

Participants

3

Reactant 2

HCID 581165611-(Thiomorpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acidHCID 178467838HCID 178467838, compound

Product 1

HCID 59606593{3-[3-(2-Ethoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone

Procedure

According to General Method 6A, 600 mg (1.491 mmol) of the compound from Example 16A and 320 mg (approx.1.983 mmol) of 3-ethoxy-N-hydroxypropanimidamide were reacted Yield: 343 mg (46% of theory)

Workup

  1. customwere reacted Yield: 343 mg (46% of theory)

Sources & evidence

ORD record
ord-240c4b8afe41430dbfa44234febb2ebb
Source dataset
uspto-grants-2013_05
Patent number
US08440657B2

Reaction notes

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