HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Thiomorpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid → {3-[3-(2-Ethoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Thiomorpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58116581 | — |
| Reactant | HCID 178467838 | HCID 178467838 | — |
| Product | {3-[3-(2-Ethoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone | HCID 59606566 | — |
Reaction Steps
According to General Method 6A, 600 mg (1.434 mmol) of the compound from Example 25A and 307 mg (approx. 1.864 mmol) of 3-ethoxy-N-hydroxypropanimidamide were reacted Yield: 403 mg (55% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440657B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-eb3d3930aa984da981db71f3490af3b4 |
| Source note | uspto-grants-2013_05 |