反应详情

温度

60 °C

1.44 g (12.8 mmol) of potassium tert-butoxide were added at RT to a solution of 528 mg (1.28 mmol) of the compound from Example 52A in 15 ml of methanol. The mixture was stirred at 60° C. overnight. For workup, the methanol was removed under reduced pressure, the residue was admixed with water and the mixture was acidified (pH 1) with aqueous 1 N hydrochloric acid solution. The mixture was extracted with ethyl acetate, and the organic phase was dried with magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 471 mg (91% of theory, 2:1 cis/trans isomer mixture)

1. customFor workup, the methanol was removed under reduced pressure
2. extractionThe mixture was extracted with ethyl acetate
3. dry with materialthe organic phase was dried with magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure