Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-[4-(1,1-Difluoroethyl)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid → {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(1,1-difluoroethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-[4-(1,1-Difluoroethyl)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58116549 | — |
| 반응물 | HCID 178513214 | HCID 178513214 | — |
| 생성물 | {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(1,1-difluoroethyl)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone | HCID 59606568 | — |
반응 단계
According to General Method 6A, 150 mg (0.376 mmol) of the compound from Example 53A and 41.5 mg (0.414 mmol) of N-hydroxycyclopropanecarboximidamide were reacted Yield: 77.9 mg (44% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08440657B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-d50ed4a6071d4ce9b32679fac6d01eeb |
| 출처 메모 | uspto-grants-2013_05 |