1H-Pyrazol-3-amine, 5-methyl- → 4-Piperidinemethanol, α,α-dimethyl-1-[[2-[(5-methyl-1H-pyrazol-3-yl)amino]-4-(4-morpholinyl)pyrido[3,2-d]pyrimidin-6-yl]methyl]-

Participants

Reaction Steps

Following General Procedure C, 5-methyl-1H-pyrazol-3-amine and 2-(1-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol from Example 8 were reacted to give 106. LCMS (MH+)=467.3. 1H-NMR (DMSO-d6): δ 11.8 (s, 1H), 8.91 (s, 1H), 7.78 (s, 1H), 7.62 (d, 1H), 6.48 (s, 1H), 4.39 (s, 4H), 3.99 (s, 1H), 3.76 (m, 4H), 3.59 (s, 2H), 2.90, (m, 2H), 2.19 (s, 3H), 1.93 (m, 2H), 1.63 (m, 2H), 1.24 (m, 2H), 1.16 (m, 1H), 1.03 (s, 6H)

Provenance & Evidence