3-(Oxan-4-yl)azetidine → HCID 86657076, compound

HRID 2091844Notes

Reaction equation

HRID 2091844 reaction equation
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]=[C:8]([Cl:19])[N:9]=[C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[C:11]=2[N:12]=1.[O:20]1[CH2:25][CH2:24][CH:23]([CH:26]2[CH2:29][NH:28][CH2:27]2)[CH2:22][CH2:21]1>>[Cl:19][C:8]1[N:9]=[C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:11]2[N:12]=[C:3]([CH2:2][N:28]3[CH2:29][CH:26]([CH:23]4[CH2:24][CH2:25][O:20][CH2:21][CH2:22]4)[CH2:27]3)[CH:4]=[CH:5][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 177856443-(Oxan-4-yl)azetidineHCID 584049784-(6-(Bromomethyl)-2-chloropyrido[3,2-D]pyrimidin-4-YL)morpholine

Product 1

HCID 86657076HCID 86657076, compound

Procedure

4-(6-(Bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine 7 (0.34 g) was reacted with 3-(tetrahydro-2H-pyran-4-yl)azetidine via General Procedure B to produce crude 4-(2-chloro-6-((3-(tetrahydro-2H-pyran-4-yl)azetidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine

Sources & evidence

ORD record
ord-01fe9dfeeeb441808e391e7904c66057
Source dataset
uspto-grants-2013_05
Patent number
US08440651B2

Reaction notes

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