HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanol → 2-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanol | HCID 53488008 | — |
| Reactant | HCID 178418287 | HCID 178418287 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carbaldehyde | HCID 53488007 | 69.5% |
Reaction Steps
(2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methanol 6 (1 g) was reacted with pyridinium chlorochromate (1.1 eq) overnight at room temperature in dichloromethane (25 mL). The reaction was filtered thru celite and run thru a silica plug to get 0.69 g of 2-chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carbaldehyde as a yellow solid after evaporation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440651B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-b770b990667c4892878f175dcc7f8669 |
| Source note | uspto-grants-2013_05 |