2-Propanol, 1-amino-2-methyl- → HCID 58405026, compound

HRID 2091893Notes

Reaction equation

HRID 2091893 reaction equation
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]=[C:8]([Cl:19])[N:9]=[C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[C:11]=2[N:12]=1.[NH2:20][CH2:21][C:22]([CH3:25])([OH:24])[CH3:23]>>[Cl:19][C:8]1[N:9]=[C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:11]2[N:12]=[C:3]([CH2:2][NH:20][CH2:21][C:22]([CH3:25])([OH:24])[CH3:23])[CH:4]=[CH:5][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 584049784-(6-(Bromomethyl)-2-chloropyrido[3,2-D]pyrimidin-4-YL)morpholine

Product 1

HCID 58405026HCID 58405026, compound

Procedure

4-(6-(Bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine 7 (0.3 g) was reacted with 1-amino-2-methylpropan-2-ol via General Procedure B to afford quantitative yield of 1-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methylamino)-2-methylpropan-2-ol.

Sources & evidence

ORD record
ord-fc2bc9255c744ab6af7bf04d7b7fd5fd
Source dataset
uspto-grants-2013_05
Patent number
US08440651B2

Reaction notes

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