3,3-Dimethylpyrrolidine → 4-(2-Chloro-6-((3,3-dimethylpyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine

HRID 2091896Notes

Reaction equation

HRID 2091896 reaction equation
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]=[C:8]([Cl:19])[N:9]=[C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[C:11]=2[N:12]=1.[CH3:20][C:21]1([CH3:26])[CH2:25][CH2:24][NH:23][CH2:22]1>>[Cl:19][C:8]1[N:9]=[C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:11]2[N:12]=[C:3]([CH2:2][N:23]3[CH2:24][CH2:25][C:21]([CH3:26])([CH3:20])[CH2:22]3)[CH:4]=[CH:5][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 149492113,3-DimethylpyrrolidineHCID 584049784-(6-(Bromomethyl)-2-chloropyrido[3,2-D]pyrimidin-4-YL)morpholine

Product 1

HCID 584049954-(2-Chloro-6-((3,3-dimethylpyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine

Procedure

4-(6-(Bromomethyl)-2-chloropyrido[3,2-d]pyrimidin-4-yl)morpholine 7 (0.225 g) was reacted with 3,3-dimethylpyrrolidine via General Procedure B to afford quantitative yield of 4-(2-chloro-6-((3,3-dimethylpyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine.

Sources & evidence

ORD record
ord-2f7aa07323404fba88aeb6d1a926e9bf
Source dataset
uspto-grants-2013_05
Patent number
US08440651B2

Reaction notes

Loading…