HRID2091907

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OB(c2c(F)ccc3c2ccn3[Si](C)(C)C(C)(C)C)OC1(C)C

HCID57506725

未命名化合物

结构：CC(=O)N1CCC(Cc2ccc3nc(Cl)nc(N4CCOCC4)c3n2)CC1

HCID58404999

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1CCC(Cc2ccc3nc(-c4c(F)ccc5[nH]ccc45)nc(N4CCOCC4)c3n2)CC1

HCID53378902

未命名化合物

PROCEDURE

实验过程

1-(4-((2-chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-1-yl)ethanone (30 mg) was reacted with 1-(tert-butyldimethylsilyl)-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole via General Procedure A to produce 13.7 mg of 148 following reverse phase HPLC purification. MS (Q1) 489.2 (M)+

WORKUP

后处理

customto produce
custom13.7 mg of 148 following reverse phase HPLC purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-65eab4dcc180409f9eff17e262d5a969
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08440651B2
来源说明: uspto-grants-2013_05

反应 SMILES

Cl[C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[N:11]=[C:10]([CH2:12][CH:13]3[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[Si]([N:35]1[C:43]2[C:38](=[C:39](B3OC(C)(C)C(C)(C)O3)[C:40]([F:44])=[CH:41][CH:42]=2)[CH:37]=[CH:36]1)(C(C)(C)C)(C)C>>[F:44][C:40]1[C:39]([C:2]2[N:3]=[C:4]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[C:5]3[N:11]=[C:10]([CH2:12][CH:13]4[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]4)[CH:9]=[CH:8][C:6]=3[N:7]=2)=[C:38]2[C:43](=[CH:42][CH:41]=1)[NH:35][CH:36]=[CH:37]2