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2,4,5-Trichloropyrimidine → (+/-)-cis-2-(2,5-Dichloropyrimidin-4-ylamino)cyclohexanecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | cis-2-Aminocyclohexanecarboxamide | HCID 2724813 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (+/-)-cis-2-(2,5-Dichloropyrimidin-4-ylamino)cyclohexanecarboxamide | HCID 86647791 | — |
反応手順
A mixture of (±)-cis-2-aminocyclohexanecarboxamide (28 mg, 0.20 mmol), 2,4,5-trichloropyrimidine (37 mg, 0.20 mmol, 1 equiv.) and NaHCO3 (17 mg, 0.20 mmol, 1 equiv.) in a mixture of MeOH (1.0 mL) and H2O (0.5 mL) is stirred at room temperature for 12 h. The reaction is diluted with EtOAc and washed with water (2×), dried over Na2SO4 and concentrated in vacuo to generate the product (±)-cis-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexanecarboxamide; ESMS m/z 289.1 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08440681B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-6d11d90deffc4de2b63a04c1097f3c80 |
| 出典メモ | uspto-grants-2013_05 |