HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2091931Generated: October 26, 2026
Sodium Carbonate → 2,5-dichloro-N-(5-phenyl-1H-pyrazol-3-yl)pyrimidin-4-amine
https://huagongshe.com/reaction/2091931
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Amino-5-phenylpyrazole | HCID 136655 | — |
| Reactant | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,5-dichloro-N-(5-phenyl-1H-pyrazol-3-yl)pyrimidin-4-amine | HCID 59586798 | — |
Reaction Steps
The mixture of 3-amino-5-phenylpyrazole (103 mg, 0.65 mmol), 2,4,5-trichloropyrimidine (74.5 μL, 0.65 mmol), and sodium carbonate (68.9 mg, 0.65) in 3 mL of EtOH is heated at 40° C. over night. The precipitate is filtered, washed by cold EtOH, and dried in vacuo to afford 2,5-Dichloro-N-(5-phenyl-1H-pyrazol-3-yl)pyrimidin-4-amine; ESMS m/z 306.0 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08440681B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-536c2dbfa8cb40d7900465d3c4faba81 |
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| Source note | uspto-grants-2013_05 |
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