Sodium Carbonate → HCID 59586787, compound

HRID 2091934Notes

Reaction equation

HRID 2091934 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH2:7])=[N:3]1.[Cl:8][C:9]1[N:14]=[C:13](Cl)[C:12]([Cl:16])=[CH:11][N:10]=1.C(=O)([O-])[O-].[Na+].[Na+]>CCO>[Cl:8][C:9]1[N:14]=[C:13]([NH:7][C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)[C:12]([Cl:16])=[CH:11][N:10]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 1372541-Methyl-3-aminopyrazoleHCID 2372592,4,5-Trichloropyrimidine

Product 1

HCID 59586787HCID 59586787, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The mixture 1-methyl-1H-pyrazol-3-amine (48 mg, 0.50 mmol), 2,4,5-trichloropyrimidine (57 μL, 0.5 mmol), and sodium carbonate (53 mg, 0.5 mmol) in 3 mL of EtOH is heated at 40° C. over night. The precipitate is filtered, washed by cold EtOH, and dried in vacuo to afford 2,5-Dichloro-N-(1-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine; ESMS m/z 244.0 (M+H+).

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed by cold EtOH
  3. customdried in vacuo

Sources & evidence

ORD record
ord-7d33d12dedb343d6a2e3a51317de155c
Source dataset
uspto-grants-2013_05
Patent number
US08440681B2

Reaction notes

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