Sodium Carbonate → HCID 178469929, compound

HRID 2091935Notes

Reaction equation

HRID 2091935 reaction equation
[NH2:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][NH:4][N:3]=1.[Cl:12][C:13]1[N:18]=[C:17](Cl)[C:16]([Cl:20])=[CH:15][N:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>CCO>[Cl:12][C:13]1[N:18]=[C:17]([NH:1][C:2]2[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][NH:4][N:3]=2)[C:16]([Cl:20])=[CH:15][N:14]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 2372592,4,5-TrichloropyrimidineHCID 178469928HCID 178469928, compound

Product 1

HCID 178469929HCID 178469929, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The mixture ethyl 3-amino-1H-pyrazole-4-carboxylate (80 mg, 0.50 mmol), 2,4,5-trichloropyrimidine (57 μL, 0.5 mmol), and sodium carbonate (53 mg, 0.5 mmol) in 3 mL of EtOH is heated at 40° C. over night. The precipitate is filtered, washed by cold EtOH, and dried in vacuo to afford ethyl 3-(2,5-dichloropyrimidin-4-ylamino)-1H-pyrazole-4-carboxylate; ESMS m/z 302.0 (M+H+).

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed by cold EtOH
  3. customdried in vacuo

Sources & evidence

ORD record
ord-4fbc18f6fa604012bc6143845bb595ca
Source dataset
uspto-grants-2013_05
Patent number
US08440681B2

Reaction notes

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