Potassium Iodide → HCID 59586790, compound

Participants

Reaction Steps

The mixture 4,6-dimethylpyridin-2-amine (61 mg, 0.50 mmol), 2,4,5-trichloropyrimidine (57 μL, 0.5 mmol), and potassium iodide (166 mg, 1.0 mmol) in 3 mL of DMA is heated at 90° C. overnight. The mixture is concentrated in vacuo and the resulting crude product is partitioned between EtOAc and brine. The collected organic extracts are dried (Na2SO4) and concentrated in vacuo to afford 2,5-dichloro-N-(4,6-dimethylpyridin-2-yl)pyrimidin-4-amine; ESMS m/z 269.0 (M+H+).

Provenance & Evidence