Nitric Acid → HCID 86647792, compound

Participants

Reaction Steps

To a solution of 2-isopropyl-5-methylphenyl trifluoromethanesulfonate (Step 1, 1.3 g, 4.6 mmol) in acetic acid (10 mL) is slowly added conc. sulfuric acid and conc. nitric acid premixed solution (2 mL/0.5 mL) at 0° C. After stifling at room temperature for 2 hours, the mixture is poured into ice water. The mixture is extracted with ethyl acetate (3×20 mL). The combined organic phase is washed with sodium carbonate aqueous solution and brine, and dried over sodium sulfate. After concentration, the crude 2-isopropyl-5-methyl-4-nitrophenyl trifluoromethanesulfonate is used directly in the next step without purification.

Provenance & Evidence