Cesium fluoride → HCID 68513860, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of crude 2-isopropyl-5-methyl-4-nitrophenyl trifluoromethanesulfonate (Step 2, 200 mg, 0.61 mmol), 4-(methylcarbamoyl)phenylboronic acid (142 mg, 0.79 mmol) and cesium fluoride (185 mg, 1.22 mmol) in dioxane (15 mL), is added palladium bis(tri-tert-butylphospine) (15 mg, 10% mmol) in a microwave tube. The tube is sealed. The mixture is purged with N2 for 3 min, and then heated at 120° C. for 10 min under microwave irradiation. The mixture is cooled, filtered and concentrated. The residue is purified with silica gel chromatography (60% ethyl acetate in hexanes) to afford white solid as 2′-isopropyl-N,5′-dimethyl-4′-nitrobiphenyl-4-carboxamide. ESMS m/z 313.2 (M+H+).

Provenance & Evidence