HCID 68513860, compound → HCID 59586785, compound

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Reaction Steps

2′-isopropyl-N,5′-dimethyl-4′-nitrobiphenyl-4-carboxamide is dissolved in methanol (20 mL). To this solution is added Pd/C (10%). The reaction mixture is degassed and purged with H2 for several times and then stirred under H2 (1 atm.) overnight. The mixture is filtered and concentrated to afford the title compound 4′-amino-2′-isopropyl-N,5′-dimethylbiphenyl-4-carboxamide as a white solid. 1H NMR (400 MHz, MeOD-d4) δ 7.87 (d, 2H, J=8.4 Hz), 7.35 (d, 2H, J=8.4 Hz), 7.31 (s, 1H), 7.14 (s, 1H), 3.00 (m, 1H), 2.95 (d, 3H), 2.36 (s, 3H), 1.15 (d, 6H, J=6.8 Hz); ESMS m/z 283.2 (M+H+).

Provenance & Evidence