Sodium Carbonate → HCID 67155404, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of the crude product from Step 1 (400 mg, 1.6 mmol), 4-(methylcarbamoyl)phenylboronic acid (286 mg, 1.6 mmol) and sodium carbonate (340 mg, 3.2 mmol) in dimethoxylethane/water (12/4 mL), is added palladium tetrakis(triphenylphospine) (93 mg, 5% mmol). The mixture is purged with N2 for 3 min, then sealed and heated at 90° C. for 3 h. The mixture is cooled, filtered and concentrated. The residue is purified with silica gel chromatography (30% ethyl acetate in DCM) to afford 5′-chloro-N,2′-dimethyl-4′-nitrobiphenyl-4-carboxamide as yellow solid. ESMS m/z 305.1 (M+H+).

Provenance & Evidence