反应详情

The mixture of methyl 5-methoxy-4′-(methylcarbamoyl)-4-nitrobiphenyl-2-carboxylate (Step 1, 275 mg, 0.75 mmol), Pd (10% wt on active carbon, 27 mg) and MeOH (20 mL) is evacuated to remove air and then the reaction is stirred under a hydrogen balloon until the starting material is consumed. Pd/C is filtered off and the filtrate is concentrated in vacuo to afford Methyl 4-amino-5-methoxy-4′-(methylcarbamoyl)biphenyl-2-carboxylate; ESMS m/z 315.1 (M+H+).

1. customis evacuated
2. customto remove air
3. customis consumed
4. filtrationPd/C is filtered off
5. concentrationthe filtrate is concentrated in vacuo