HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → Methyl 2-((2,5-dichloropyrimidin-4-yl)amino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 2-(2,5-Dichloropyrimidin-4-ylamino)benzoic acid | HCID 71501536 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | Methyl 2-((2,5-dichloropyrimidin-4-yl)amino)benzoate | HCID 86647794 | — |
Reaction Steps
To a solution of 2-(2,5-dichloropyrimidin-4-ylamino)benzoic acid (300 mg, 1.1 mmol) in DCM/MeOH (10/5 mL) is added trimethylsilyl diazomethane in ethyl ether solution (2.0 M, 2 mL). The mixture is stirred for 30 min and concentrated to afford methyl 2-(2,5-dichloropyrimidin-4-ylamino)benzoate as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440681B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-d8a10ade9d9148cd9135202927534141 |
| Source note | uspto-grants-2013_05 |