2-[(2,5-Dichloropyrimidin-4-yl)amino]benzamide → HCID 25265267, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of methyl 4-amino-5-methoxy-4′-(methylcarbamoyl)biphenyl-2-carboxylate (Intermediate 27, 117 mg, 0.37 mmol) and 2-(2,5-dichloropyrimidin-4-ylamino)benzamide (Intermediate 3, 316 mg, 1.12 mmol) in 3 mL of i-PrOH is added 5 drops of conc. aqueous HCl. The reaction mixture is heated at 150° C. in a microwave reactor for 30 min, followed by concentration and purification by silica gel chromatography (MeOH/DCM: 1/9) to afford methyl 4-(4-(2-carbamoylphenylamino)-5-chloropyrimidin-2-ylamino)-5-methoxy-4′-(methylcarbamoyl)biphenyl-2-carboxylate; ESMS m/z 561.2 (M+H+).

Provenance & Evidence