Pyrrolidine → HCID 86761837, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of methyl 4-(4-(2-carbamoylphenylamino)-5-chloropyrimidin-2-ylamino)-5-methoxy-4′-(methylcarbamoyl)biphenyl-2-carboxylate (Step 1, 220 mg, 0.75 mmol) and 1 mL of pyrrolidine is heated at 100° C. overnight. The crude is concentrated in vacuo and applied to preparative RP-HPLC to afford 4′-(4-(2-Carbamoylphenylamino)-5-chloropyrimidin-2-ylamino)-5′-methoxy-N-methyl-2′-(pyrrolidine-1-carbonyl)biphenyl-4-carboxamide; ESMS m/z 600.2 (M+H+).

Provenance & Evidence