HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 2-chloro-N-(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)phenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 4-(4-aminophenyl)-N-(4-morpholinophenyl)pyrimidin-2-amine | HCID 24878015 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-chloro-N-(4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)phenyl)acetamide | HCID 57990913 | — |
Reaction Steps
To a flask charged with 4-(4-aminophenyl)-N-(4-morpholinophenyl)pyrimidin-2-amine (100 mg, 0.286 mmol) and THF (1 mL) was added chloroacetyl chloride (0.0230 mL, 0.286 mmol). The solution was stirred at ambient temperature for 1 hour. The crude mixture was then concentrated and used without further purification. LCMS: m/z 424 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440663B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-882c2872663f483abf9c2e654ae8217f |
| Source note | uspto-grants-2013_05 |