Thiophosgene → 5-Bromo-6-isothiocyanatoquinoxaline

HRID 2092005Notes

Reaction equation

HRID 2092005 reaction equation
Br.[NH2:2][C:3]1[C:4]([Br:13])=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[N:6]2.[C:14](Cl)(Cl)=[S:15]>O>[Br:13][C:4]1[C:3]([N:2]=[C:14]=[S:15])=[CH:12][CH:11]=[C:10]2[C:5]=1[N:6]=[CH:7][CH:8]=[N:9]2

Participants

4

Reactant 2

HCID 10040ThiophosgeneHCID 183506656-Amino-5-bromoquinoxaline hydrobromide

Product 1

HCID 44602745-Bromo-6-isothiocyanatoquinoxaline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 6-amino-5-bromoquinoxaline hydrobromide (10 g) in distilled water (150 ml) is added thiophosgene (3 ml). The solution is stirred for two hours at room temperature and the resultant precipitate is collected by filtration, washed with water, and dried to afford 5-bromo-6-isothiocyanato-quinoxaline.

Workup

  1. filtrationthe resultant precipitate is collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-e9d07fddf886466f90f441150278fdb7
Source dataset
uspto-grants-2013_05
Patent number
US08440688B2

Reaction notes

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