HCID 68432187, compound → HCID 68429245, compound

Participants

Reaction Steps

rac-2-{2-[(Methoxymethoxy)methyl]-6,6-dimethylbicyclo[3.1.1]hept-3-yl}-1H-isoindole-1,3(2H)-dione (0.97 g, 2.82 mmol) was stirred with hydrogen chloride-methanol (20 mL, 10% w/v) at room temperature for 1 day. After completion of the reaction, the reaction solution was evaporated under reduced pressure, and the residue was mixed with saturated aqueous sodium hydrogen carbonate and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to give the desired product (100% yield).

Provenance & Evidence