HCID 68429245, compound → HCID 72330250, compound

Participants

Reaction Steps

rac-2-[2-(Hydroxymethyl)-6,6-dimethylbicyclo[3.1.1]hept-3-yl]-1H-isoindole-1,3(2H)-dione (750 mg, 2.51 mmol), silica gel (0.75 g) and pyridinium chlorochromate (1.08 g, 5.01 mmol) were stirred in dichloromethane (20 mL) at room temperature for 2 hours. After completion of the reaction, the reaction solution was filtered through celite, and the filtrate was evaporated. The resulting residue was purified by column chromatography (hexane/ethyl acetate=5/1→3/1) to give the desired product (61% yield).

Provenance & Evidence