HCID 59574604, compound → HCID 68430436, compound

HRID 2092042Notes

Reaction equation

HRID 2092042 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([O:8][CH3:9])=[C:4]([CH:10]([NH2:12])[CH3:11])[CH:3]=1>CO.[C].[Pd]>[ClH:1].[CH3:9][O:8][C:5]1[N:6]=[N:7][CH:2]=[CH:3][C:4]=1[CH:10]([NH2:12])[CH3:11]

Participants

4

Reactant 1

HCID 59574604HCID 59574604, compound

Product 1

HCID 68430436HCID 68430436, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1-(6-Chloro-3-methoxypyridazin-4-yl)ethanamine (67.3 mg, 0.36 mmol) and 10% palladium-carbon (50 wt %, 20 mg) were stirred in methanol (5 mL) under hydrogen atmosphere (1 atm) at room temperature for 16 hours. After filtering through celite, the filtrate was evaporated under reduced pressure. The resulting crude reaction product was used for the next step.

Workup

  1. filtrationAfter filtering through celite
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe resulting crude reaction product

Sources & evidence

ORD record
ord-13ea2ffd47e44c6d8a18692a6f95af0e
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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