Ethyl Acetate → HCID 68431388, compound

Participants

Reaction Steps

Ethyl 2-{5-bromo-6-oxo-4-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-1(6H)-yl}acetate (646 mg, 1.57 mmol) in 1,4-dioxane (6.5 mL) was mixed with 1 M aqueous sodium hydroxide (4.71 mL, 4.71 mmol) and stirred at room temperature for 1 hour. After completion of the reaction, ethyl acetate was added, and the organic layer was washed with 1 M hydrochloric acid and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and evaporated under reduced pressure to give the desired product (567 mg, 94% yield).

Provenance & Evidence