Potassium Carbonate → HCID 68432192, compound

Participants

Reaction Conditions

Reaction Steps

4-Bromo-5-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-3(2H)-one (224 mg, 0.688 mmol) in N,N-dimethylformamide (2.2 mL) was mixed with ethyl 4-bromobutyrate (0.148 mL, 1.03 mmol) and potassium carbonate (142 mg, 1.03 mmol) at room temperature and stirred at 80° C. for 2 hours. After cooling, the reaction solution was mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate. The resulting organic layer was washed with saturated aqueous ammonium chloride and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and evaporated under reduced pressure to give the desired product (454 mg, quant.).

Provenance & Evidence