Triethylamine → 2-[5-Bromo-4-(1,1,3,3-tetramethylbutylamino)-6-oxopyridazin-1(6H)-yl]-N-(pyridin-4-ylmethyl)acetamide

関与物質

反応手順

2-(4,5-Dibromo-6-oxopyridazin-1(6H)-yl)-N-(pyridin-4-ylmethyl)acetamide (50 mg, 124 μmol) in dioxane-water (1:1, 2 mL) was stirred with triethylamine (52 μL, 372 μmol) and 2,5,5-trimethylhexan-2-amine (16 mg, 112 μmol) at 90° C. for 26 hours. After completion of the reaction, the solvent was removed by vacuum distillation, and the residue was mixed with saturated aqueous sodium chloride and extracted with chloroform three times. The combined organic layer was dried over anhydrous magnesium sulfate, and the solvent was removed by vacuum distillation. The resulting residue was purified by silica gel chromatography (chloroform/methanol=10/1) to give the desired product (13 mg, 25% yield).

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