HCID 68430567, compound → HCID 68429465, compound

HRID 2092076Notes

Reaction equation

HRID 2092076 reaction equation
Cl[C:2]1[C:3](=[O:22])[NH:4][N:5]=[C:6]([O:19][CH2:20][CH3:21])[C:7]=1[NH:8][C@@H:9]1[CH2:14][C@@H:13]2[CH2:15][C@@H:11]([C:12]2([CH3:17])[CH3:16])[C@H:10]1[CH3:18].[H][H]>CO.[C].[Pd]>[CH2:20]([O:19][C:6]1[C:7]([NH:8][C@@H:9]2[CH2:14][C@@H:13]3[CH2:15][C@@H:11]([C:12]3([CH3:16])[CH3:17])[C@H:10]2[CH3:18])=[CH:2][C:3](=[O:22])[NH:4][N:5]=1)[CH3:21]

Participants

5

Reactant 2

HCID 68430567HCID 68430567, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68429465HCID 68429465, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

4-Chloro-6-ethoxy-5-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-3(2H)-one (200 mg, 0.614 mmol) and 10% palladium-carbon (50 wt %, 40 mg) were stirred in methanol in a hydrogen stream at room temperature for 8 days. The reaction solution was filtered through celite and concentrated under reduced pressure to give the desired product (94% yield).

Workup

  1. filtrationThe reaction solution was filtered through celite and
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e662be7d05e94b00bfac88a127ea4b85
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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