反应详情

温度

120 °C

2-{5-Bromo-6-oxo-4-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-1(6H)-yl}-N-(pyridin-4-ylmethyl)acetamide (99 mg, 0.208 mmol) in toluene (1 mL) was mixed with Lawesson's reagent (168 mg, 0.416 mmol) and refluxed at 120° C. for 1 hour. After cooling, the reaction solution was evaporated under reduced pressure. The resulting residue was purified by silica gel chromatography (chloroform/methanol=50/1) to give the desired product (28 mg, 27% yield).

1. temperatureAfter cooling
2. customthe reaction solution was evaporated under reduced pressure
3. customThe resulting residue was purified by silica gel chromatography (chloroform/methanol=50/1)