Water → HCID 68432076, compound

Participants

Reaction Steps

2-(5-Chloro-6-oxo-4-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-1(6H)-yl)-N-(pyridin-4-ylmethyl)acetamide (40 mg, 0.0873 mmol) was added to lithium aluminum hydride (4.3 mg, 0.104 mmol) in tetrahydrofuran (1 mL) at 0° C., and the resulting reaction solution was stirred at room temperature for 1.5 hours. After completion of the reaction, the reaction solution was mixed with water, ethyl acetate and anhydrous magnesium sulfate and filtered, and the filtrate was evaporated under reduced pressure. The resulting residue was purified by preparative thin layer chromatography (chloroform/methanol=13/1) to give the desired product (9.5 mg, 25% yield).

Provenance & Evidence