Hydrochloride methanol → HCID 178461481, compound

Participants

Reaction Steps

2-[5-Chloro-6-oxo-4-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}-3-{[2-(trimethylsilyl)ethoxy]methoxy}pyridazin-1(6H)-yl]-N-(pyridin-4-ylmethyl)acetamide (12 mg, 0.0208 mmol) in methanol (1 mL) was stirred with 10 mass % hydrogen chloride-methanol (5 mL) at 60° C. for 5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and purified by preparative HPLC to give the desired product.

Provenance & Evidence