Nitric Acid → 4,5-Dibromo-6-nitropyridazin-3(2H)-one

Participants

Reaction Steps

To 4,5-dibromopyridazin-3(2H)-one (2 g, 7.87 mmol) in concentrated sulfuric acid (12 mL), fuming nitric acid (978 μL, 23.8 mmol) was gradually added at 100° C. with stirring, and the resulting reaction solution was stirred at 100° C. for 3 hours. After completion of the reaction, the reaction solution was cooled to room temperature and poured onto ice-cold water. The precipitated crystals were collected by filtration and dried under reduced pressure to give the desired product (2.2 g, 93%).

Provenance & Evidence