Hydrochloric Acid → HCID 68430987, compound

Participants

Reaction Steps

Ethyl 2-[5-bromo-6-oxo-4-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-1(6H)-yl]-3-(pyridin-4-yl)propanoate (165 mg, 0.294 mmol) in 1,4-dioxane (4 mL) was stirred with 1 M aqueous sodium hydroxide (1 mL) at room temperature for 4 hours. After completion of the reaction, the reaction solution was neutralized with 1 M hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and evaporated under reduced pressure to give the desired product (156 mg, quant).

Provenance & Evidence